Recent Publications
378
Aryl Azocyclopropeniums: Minimalist, Visible-Light Photoswitches
M. Fink, J. Stäuble, M. Weisgerber, E. M. Carreira, J. Am. Chem. Soc. 2024, ASAP.
external pagehttps://pubs.acs.org/doi/10.1021/jacs.4c01786call_made
377
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
M. Kosar, R. C. Sarott, D. A. Sykes, A. E. G. Viray, R. M. Vitale, N. Tomašević, X. Li, R. L. Z. Ganzoni, B. Kicin, L. Reichert, K. J. Patej, U. Gómez-Bouzó, W. Guba, P. J. McCormick, T. Hua, C. W. Gruber, D. B. Veprintsev, J. A. Frank, U. Grether, E. M. Carreira, ACS Cent. Sci. 2024, ASAP.
external pagehttps://pubs.acs.org/doi/10.1021/acscentsci.3c01461call_made
376
Photo- and Cobalt-Catalyzed Synthesis of Heterocycles via Cycloisomerization of Unactivated Olefins
H. Lindner, W. M. Amberg, T. Martini, D. M. Fischer, E. Moore, E. M. Carreira, Angew. Chem. Int. Ed. 2024, e202319515.
external pagehttps://onlinelibrary.wiley.com/doi/10.1002/ange.202319515call_made
375
Harnessing PROTAC technology to combat stress hormone receptor activation
M. Gazorpak, K. M. Hugentobler, D. Paul, P.-L. Germain, M. Kretschmer, I. Ivanova, S. Frei, K. Mathis, R. Rudolf, S. M. Barrenechea, V. Fischer, X. Xue, A. L. Ptaszek, J. Holzinger, M. Privitera, A. Hierlemann, O. C. Meijer, R. Konrat, E. M. Carreira, J. Bohacek & K. Gapp, Nat. Commun. 2023, 14, 8177.
external pagehttps://www.nature.com/articles/s41467-023-44031-2call_made
374
A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging
C. Thomas, R. Erni, J. Y. Wu, F. Fischer, G. Lamers, G. Grigolon, S. J. Mitchell, K. Zarse, E. M. Carreira & M. Ristow, Nat. Commun. 2023, 14, 8142.
external pagehttps://www.nature.com/articles/s41467-023-43672-7call_made
373
Total Synthesis of (+)-Euphorikanin A via an Atropospecific Cascade
M. J. Classen, B. Kicin, V. A. P. Ruf, A. Hamminger, L. Ribadeau-Dumas, W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc. 2023, ASAP.
external pagehttps://pubs.acs.org/doi/10.1021/jacs.3c11000call_made
372
Iron-Mediated Photochemical Anti-Markovnikov Hydroazidation of Unactivated Olefins
H. Lindner, W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc. 2023, 145, 22347–22353.
external pagehttps://pubs.acs.org/doi/full/10.1021/jacs.3c09122call_made
371
Enantioselective Total Syntheses of Cassane Furanoditerpenoids and Their Stimulation of Cellular Respirationin Brown Adipocytes
H. H. Bulthaupt, F. Glatz, S. M. Papidocha, C. Wu, S. Teh, S. Wolfrum, L. Balážová, C. Wolfrum, E. M. Carreira, J. Am. Chem. Soc. 2023, 145, 21562–21568.
370
Synthesis of Neocaesalpin A, AA, and Nominal Neocaesalpin K
S. M. Papidocha, H. H. Bulthaupt, E. M. Carreira, Angew. Chem. Int. Ed. 2023, e202310149.
external pagehttps://doi.org/10.1002/anie.202310149call_made
369
Cobalt-Catalyzed Aerobic Aminocyclization of Unsaturated Amides for the Synthesis of Functionalized γ- and δ-Lactams
M. Freis, M. Balkenhohl, D. M. Fischer, T. Georgiev, R. C. Sarott, E. M. Carreira, Org. Lett. 2023, 25, 6380–6384.
external pagehttps://doi.org/10.1021/acs.orglett.3c02390call_made
368
Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells
M. Kosar, D. A. Sykes, A. E. G. Viray, R. M. Vitale, R. C. Sarott, R. L. Ganzoni, D. Onion, J. M. Tobias, P. Leippe, C. Ullmer, E. A. Zirwes, W. Guba, U. Grether, J. A. Frank, D. B. Veprintsev, E. M. Carreira, J. Am. Chem. Soc., 2023, 145, 15094–15108.
367
Organophotocatalytic carbo-heterofunctionalization of unactivated olefins with pendant nucleophiles
D. M. Fischer, M. Freis, W. M. Amberg, H. Lindner, E. M. Carreira, Chem. Sci., 2023, 14, 7256-726.
366
Enantioselective Total Synthesis of (+)-Pedrolide
M. Fadel, E. M. Carreira, J. Am. Chem. Soc., 2023, 145, 8332–8337.
365
Role of Noncovalent Interactions in Inducing High Enantioselectivity in an Alcohol Reductive Deoxygenation Reaction Involving a Planar Carbocationic Intermediate
S. Ghosh, A. Changotra, D. A. Petrone, M. Isomura, E. M. Carreira, R. B. Sunoj, J. Am. Chem. Soc., 2023, 145, 2884–2900.
364
Conformational Diversity in Partially Fluorinated N-Alkyl Pipecolic Acid Amide Derivatives
N. Trapp, M. Wörle, B. Kuhn, P. Gerber, R. Vorberg, E. M. Carreira, K. Müller, Helv. Chim. Acta, 2023, 106, e202200146.
external pagehttps://doi.org/10.1002/hlca.202200146call_made
363
Intermolecular Organophotocatalytic Cyclopropanation of Unactivated Olefins
D. M. Fischer, H. Lindner, W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc., 2023, 145, 774–780.
362
Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium
R. Ueoka, P. Sondermann, S. Leopold-Messer, Y. Liu, R. Suo, A, Bhushan, L. Vadakumchery, U. Greczmiel, Y. Yashiroda, H. Kimura, S. Nishimura, Y. Hoshikawa, M. Yoshida, A. Oxenius, S. Matsunaga, R. T. Williamson, E. M. Carreira, J. Piel, Nat. Chem., 2022, 14, 1193–1201.
external pagehttps://doi.org/10.1038/s41557-022-01020-0call_made
361
Enantioselective Total Synthesis of (+)-Aberrarone
W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc., 2022, 144, 15475–15479.
360
Carbon Nitride Photoredox Catalysis Enables the Generation of the Dioxolanyl Radical for Conjugate Addition Reactions
V. C. Gerken, E. M. Carreira, ACS Catal., 2022, 12, 10787–10792.
external pagehttps://doi.org/10.1021/acscatal.2c03229call_made
359
Ritter reaction for the synthesis of picolinamides
B. S. Schreib, J. Margarini, E. M. Carreira, Tetrahedron, 2022, 132937.
external pagehttps://doi.org/10.1016/j.tet.2022.132937call_made
358
Reverse-Design toward Optimized Labeled Chemical Probes – Examples from the Endocannabinoid System
M. Guberman, M. Kosar, A. Omran, E. M. Carreira, M. Nazaré, U. Grether, Chimia, 2022, 76, 425-434.
external pagehttps://doi.org/10.2533/chimia.2022.425call_made
357
Total Synthesis of Mutanobactins A, B from the Human Microbiome: Macrocyclization and Thiazepanone Assembly in a Single-Step
M. E. Hansen, S. O. Yasmin, S. Wolfrum, E. M. Carreira, Angew. Chem. Int. Ed., 2022, e202203051.
external pagehttps://doi.org/10.1002/anie.202203051call_made
356
Cobalt-Catalyzed Cyclization of Unsaturated N-Acyl Sulfonamides: a Diverted Mukaiyama Hydration Reaction
D. M. Fischer, M. Balkenhohl, E. M. Carreira, JACS Au, 2022, 2, 1071–1077.
external pagehttps://doi.org/10.1021/jacsau.2c00186call_made
355
Picolinamides and Iodoalkynes Enable Palladium-Catalyzed syn-Aminoalkynylation of Di- and Trisubstituted Alkenes to Give Pyrrolidines
N. Müller, B. S. Schreib, S. U. Leutenegger, E. M. Carreira, Angew. Chem. Int. Ed., 2022, e202204535.
external pagehttps://doi.org/10.1002/anie.202204535call_made
354
Detection of Cannabinoid Receptor Type 2 in Native Cells and Zebrafish with a Highly Potent, Cell-Permeable Fluorescent Probe
T. Gazzi, B. Brennecke, K. Atz, C. Korn, D. Sykes, G. Forn-Cuni, P. Pfaff, R. C. Sarott, M. V. Westphal, Y. Mostinski, L. Mach, M. Wasinska-Kalwa, M. Weise, B. L. Hoare, T. Miljuš, M. Mexi, N. Roth, E. J. Koers, W. Guba, A. Alker, A. C. Rufer, E. A. Kusznir, S. Huber, C. Raposo, E. A. Zirwes, A. Osterwald, A. Pavlovic, S. Moes, J. Beck, M. Nettekoven, I. Benito-Cuesta, T. Grande, F. Drawnel, G. Widmer, D. Holzer, T. van der Wel, H. Mandhair, M. Honer, J. Fingerle, J. Scheffel, J. Broichhagen, K. Gawrisch, J. Romero, C. J. Hillard, Z. V. Varga, M. van der Stelt, P. Pacher, J. Gertsch, C. Ullmer, P. J. McCormick, S. Oddi, H. Spaink, M. Maccarrone, D. Veprintsev, E. M. Carreira, U. Grether, M. Nazare , Chem. Sci., 2022, 13, 5539-5545.
354
Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan
G. Grigolon, E. Araldi, R. Erni, J. Y. Wu, C.Thomas, M. La Fortezza, B. Laube, D. Pöhlmann, M. Stoffel, K. Zarse, E. M. Carreira, M. Ristow, F. Fischer, Nat. Commun., 2022, 13, 107 .
external pagehttps://doi.org/10.1038/s41467-021-27732-4call_made
353
Total Synthesis of Shearinines D and G: A Convergent Approach to Indole Diterpenoids
N. Hauser, M. A. Imhof, S. S. Eichenberger, T. Kündig, E. M. Carreira, Angew. Chem. Int. Ed., 2022, 61, e202112838.
external pagehttps://doi.org/10.1002/anie.202112838call_made
352
Allene C(sp2)–H Activation and Alkenylation Catalyzed by Palladium
B. S. Schreib, M. Son, F. A. Aouane, M.-H. Baik, E. M. Carreira, J. Am. Chem. Soc., 2021, 143, 21705–21712.
351
Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks
M. Müller, F. Gräbnitz, N. Barandun, Y. Shen, F. Wendt, S. N. Steiner, Y. Severin, S. U. Vetterli, M. Mondal, J. R. Prudent, R. Hofmann, M. van Oostrum, R. C. Sarott, A. I. Nesvizhskii, E. M. Carreira, J. W. Bode, B. Snijder, J. A. Robinson, M. J. Loessner, A. Oxenius, B. Wollscheid, Nat. Commun., 2021, 12, 7036.
external pagehttps://doi.org/10.1038/s41467-021-27280-xcall_made
350
Azoacetylenes for the Synthesis of Arylazotriazole Photoswitches
P. Pfaff, F. Anderl, M. Fink, M. Balkenhohl, E. M. Carreira, J. Am. Chem. Soc, 2021, 143, 14495–14501.
349
Δ9-cis-Tetrahydrocannabinol: Natural Occurrence, Chirality, and Pharmacology
M. A. Schafroth, G. Mazzoccanti, I. Reynoso-Moreno, R. Erni, F. Pollastro, D. Caprioglio, B. Botta, G. Allegrone, G. Grassi, A. Chicca, F. Gasparrini, J. Gertsch, E. M. Carreira, G. Appendino, J. Nat. Prod., 2021, 84, 2502–2510.
external pagehttps://doi.org/10.1021/acs.jnatprod.1c00513call_made
348
Mutanobactin D from the Human Microbiome: Total Synthesis, Configurational Assignment, and Biological Evaluation
F. Pultar, M. E. Hansen, S. Wolfrum, L. Böselt, R. Fróis-Martins, S. Bloch, A. G. Kravina, D. Pehlivanoglu, C. Schäffer, S. LeibundGut-Landmann, S. Riniker, E. M. Carreira, J. Am. Chem. Soc., 2021, 143, 10389–10402.
347
Mn- and Co-Catalyzed Aminocyclizations of Unsaturated Hydrazones Providing a Broad Range of Functionalized Pyrazolines
M. Balkenhohl, S. Kölbl, T. Georgiev, E. M. Carreira, JACS Au, 2021, 1, 919–924.
external pagehttps://doi.org/10.1021/jacsau.1c00176call_made
346
Enantioselective Total Synthesis of (+)-Euphorikanin A
M. J. Classen, M. N. A. Böcker, R. Roth, W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc., 2021, 143, 8261–8265.
345
Enantio- and Chemoselective Intramolecular Iridium-Catalyzed O-Allylation of Oximes
T. Sandmeier, E. M. Carreira, Org. Lett., 2021, 23, 2643–2647.
external pagehttps://doi.org/10.1021/acs.orglett.1c00559call_made
344
Construction of Vicinal Quaternary Centers via Iridium-Catalyzed Asymmetric Allenylic Alkylation of Racemic Tertiary Alcohols
M. Isomura, D. A. Petrone, E. M. Carreira, J. Am. Chem. Soc., 2021, 143, 3323–3329.
343
Enantioselective Synthesis of Cyclic Nitrones by Chemoselective Intramolecular Allylic Alkylation of Oximes
T. Sandmeier, E. M. Carreira, Angew. Chem. Int. Ed., 2021, 60, 9913– 9918.
external pagehttps://doi.org/10.1002/anie.202100150call_made
342
Discovery and Surprises with Cyclizations, Cycloadditions, Fragmentations, and Rearrangements in Complex Settings
K. M. Hugentobler, E. M. Carreira, Acc. Chem. Res., 2021, 54, 890–902.
external pagehttps://doi.org/10.1021/acs.accounts.0c00814call_made
341
Optical Control of Cannabinoid Receptor 2‑Mediated Ca2+ Release Enabled by Synthesis of Photoswitchable Probes
R. C. Sarott, A. E. G. Viray, P. Pfaff, A. Sadybekov, G. Rajic, V. Katritch, E. M. Carreira, J. A. Frank, J. Am. Chem. Soc., 2021, 143, 736–743.
340
Modern Catalytic Enantioselective Approaches to Piperidines
T. Sandmeier, E. M. Carreira. In Synthetic Approaches to Nonaromatic Nitrogen Heterocycles; A. M. M. M. Faisca Phillips, Ed.; John Wiley & Sons, Inc.: Hoboken, New Jersey, 2010; pp 249–271.
external pagehttps://doi.org/10.1002/9781119708841.ch10call_made
339
Total Synthesis of (−)-Mitrephorone A Enabled by Stereoselective Nitrile Oxide Cycloaddition and Tetrasubstituted Olefin Synthesis
M. Schneider, M. J. R. Richter, and E. M Carreira, J. Am. Chem. Soc., 2020, 142, 17802–17809.
338
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
R. C. Sarott, M. Westphal, P. Pfaff, C. Korn, D. A. Sykes, T. Gazzi, B. Brennecke, K. Atz, M. Weise, Y. Mostinski, P. Hompluem, E. Koers, T. Miljus, N. J. Roth, H. Asmelash, M. C. Vong, J. Piovesan, W. Guba, A. Rufer, E. A.Kusznir, S. Huber, C. Raposo, E. A. Zirwes, A. Osterwald, A. Pavlovic, S. Moes, J. Beck, I. Benito-Cuesta, T. Grande, S. Ruiz de Martin, A. A. Yeliseev, F. Drawnel, G. Widmer, D. Holzer, T. van der Wel, H. Mandhair, C. Yuan, W. Drobyski, Y. Saroz, N. L. Grimsey, M. Honer, J. Fingerle, K. Gawrisch, J. Romero, C. Hillard, Z. Varga, M. van der Stelt, P. Pacher, J. Gertsch, P. McCormick, C. Ullmer, S. Oddi, M. Maccarrone, D. Veprintsev, M. Nazaré, U. Grether, and E. M Carreira, J. Am. Chem. Soc., 2020, 142, 16953–16964.
337
Activation of Copper Species on Carbon Nitride for Enhanced Activity in the Arylation of Amines
E. Vorobyeva, V. C. Gerken, S. Mitchell, A. Sabadell-Rendón, R. Hauert, S. Xi, A. Borgna, D. Klose, S. M. Collins, P. A. Midgley, D. M. Kepaptsoglou, Q. M. Ramasse, A. Ruiz-Ferrando, E. Fako, M. A. Ortuño, N. Lopez, E. M. Carreira, and J. Pérez-Ramírez, ACS Catal, 2020, 10, 11069–11080.
external pagehttps://doi.org/10.1021/acscatal.0c03164call_made
336
Ir‐Catalyzed Enantioconvergent Synthesis of Diversely Protected Allenylic Amines Employing Ammonia Surrogates
F. Glatz, D. A. Petrone, and E. M. Carreira, Angew. Chem. Int. Ed. 2020, 59, 16404–16408.
external pagehttps://doi.org/10.1002/anie.202005599call_made
335
Derailed Ohira-Bestmann Reaction of γ,δ-Unsaturated Aldehydes for the Stereoselective Synthesis of Cyclopenta[c]pyrazoles
T. Sandmeier, N. Sievertsen, and E. M. Carreira, Helv. Chim. Acta 2020, 103, e2000058.
external pagehttps://doi.org/10.1002/hlca.202000058call_made
334
Ring-Fused Cyclobutanes via Cycloisomerization of Alkylidenecyclopropane Acylsilanes
S. Eichenberger, M. Hönig, M.J.R. Richter, R. Gershoni-Poranne, and E. M. Carreira, Chem. Sci., 2020, 11, 5294–5298.
333
The Serendipitous Discovery of a Rose Odorant
N. Hauser, P. Kraf, E. M. Carreira, Chimia 2020, 74, 247–251.
external pagehttps://doi.org/10.2533/chimia.2020.247call_made
332
Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways
J. Muri, Q. Feng, H. Wolleb, A. Shamshiev, C. Ebner, L. Tortola, P. Broz, E. M. Carreira, M. Kopf, Cell Reports, 2020, 30, 4399–4417.
external pagehttps://doi.org/10.1016/j.celrep.2020.03.019call_made
331
Molecular Recognition and Cocrystallization of Methylated and Halogenated Fragments of Danicalipin A by Enantiopure Alleno-Acetylenic Cage Receptors
C. Gropp, S. Fischer, T. Husch, N. Trapp, E. M. Carreira, F. Diederich, J. Am. Chem. Soc. 2020, 142, 4749–4755.
external pagehttps://doi.org/10.1021/jacs.9b13217call_made
330
Palladium-Catalyzed C–H Alkynylation of Unactivated Alkenes
B. S. Schreib, M. Fadel, E. M. Carreira, Angew. Chem. Int. Ed. 2020, 59, 7818 –7822.
external pagehttps://doi.org/10.1002/anie.202000935call_made
329
Highly Selective, Amine-Derived Cannabinoid Receptor 2 Probes
M. V. Westphal, R. C. Sarott, E. A. Zirwes, A. Osterwald, W. Guba, C. Ullmer, U. Grether, E. M. Carreira, Chem. Eur. J. 2020, 26, 1380–1387.
external pagehttps://doi.org/10.1002/chem.201904584call_made
328
Enantioselective Iridium-Catalyzed α-Allylation with Aqueous Solutions of Acetaldehyde
T. Sandmeier, E. M. Carreira, Org. Lett. 2020, 22, 1135–1138.
external pagehttps://doi.org/10.1021/acs.orglett.9b04658call_made
327
Total Synthesis and Structural Revision of a Harziane Diterpenoid
M. Hönig, E. M. Carreira, Angew. Chem. Int. Ed. 2020, 59, 1192–1196.
external pagehttps://doi.org/10.1002/anie.201912982call_made
326
The Catalytic, Enantioselective Favorskii Reaction: In Situ Formation of Metal Alkynylides and Their Additions to Aldehydes
Y. Sempere, E. M. Carreira, book chapter in S.E. Denmark et al., "Organic Reactions", Vol 100, Wiley, 2020.
external pagehttps://doi.org/10.1002/0471264180.or100.04call_made
325
Pyridinium Salts as Redox‐Active Functional Group Transfer Reagents
S.L. Rössler, B.J. Jelier, E. Magnier, G. Dagousset, E. M. Carreira, A. Togni, Angew. Chem. Int. Ed. 2020, 59, 9264–9280.
external pagehttp://dx.doi.org/10.1002/anie.201911660call_made
324
Asymmetric Synthesis of the Tricyclooctane Core of Trachylobane Natural Products and Related Terpenoids
M. Schneider, M. J. R. Richter, S. Krautwald, E. M. Carreira, Org. Lett. 2019, 21, 8705-8707.
external pagehttps://doi.org/10.1021/acs.orglett.9b03303call_made
323
Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs
P. Pfaff, K. T. G. Samarasinghe, C. M. Crews, E. M. Carreira, ACS Cent. Sci. 2019, 5, 1682-1690.
external pagehttps://doi.org/10.1021/acscentsci.9b00713call_made
322
Gold(I)-catalyzed stereoselective cyclization of 1,3-enyne aldehydes by a 1,3-acyloxy migration/Nazarov cyclization/aldol addition cascade
M. Brandstätter, N. Huwyler, E.M. Carreira, Chem. Sci. 2019, 10, 8219–8223 .
external pagehttps://doi.org/10.1039/C9SC02828Ecall_made
321
Iridium-Catalyzed Enantioselective Allylic Substitution with Aqueous Solutions of Nucleophiles
T. Sandmeier, F.W. Goetzke, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2019, 141, 12212–12218.
external pagehttps://doi.org/10.1021/jacs.9b05830call_made
320
Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands
S.L. Rössler, D.A. Petrone, E.M. Carreira, Acc. Chem. Res. 2019, 52, 2657–2672.
external pagehttps://doi.org/10.1021/acs.accounts.9b00209call_made
319
Stereochemical Revision, Total Synthesis, and Solution State Conformation of the Complex Chlorosulfolipid Mytilipin B
P. Sondermann, E.M. Carreira, J. Am. Chem. Soc. 2019, 141, 10510–10519.
external pagehttps://doi.org/10.1021/jacs.9b05013call_made
318
Morpholine Ketene Aminal as Amide Enolate Surrogate in Iridium‐Catalyzed Asymmetric Allylic Alkylation
Y. Sempere, J.L. Alfke, S.L. Rössler, E.M. Carreira, Angew. Chem. Int. Ed., 2019, 58, 9537–9541.
external pagehttps://doi.org/10.1002/anie.201903090call_made
317
Palladium-Catalyzed Regioselective C−H Iodination of Unactivated Alkenes
B.S. Schreib, E.M. Carreira, J. Am. Chem. Soc., 2019, 141, 8758–8763.
external pagehttps://doi.org/10.1021/jacs.9b03998call_made
316
Coordination-Induced Stereocontrol over Carbocations: Asymmetric Reductive Deoxygenation of Racemic Tertiary Alcohols
M. Isomura, D.A. Petrone, E.M. Carreira, J. Am. Chem. Soc., 2019, 141, 4738–4748.
external pagehttps://doi.org/10.1021/jacs.9b00862call_made
315
Total Synthesis of (–)-Merochlorin A
M. Brandstätter, M. Freis, N. Huwyler, E.M. Carreira, Angew. Chem. Int. Ed. 2019, 58, 2490–2494.
external pagehttps://doi.org/10.1002/anie.201813090call_made
314
Pyridyl Radical Cation for C–H Amination of Arenes
S.L. Rössler, B.J. Jelier, P.F. Tripet, A. Shemet, G. Jeschke, A. Togni, E.M. Carreira, Angew. Chem. Int. Ed. 2019, 131, 536 –541.
external pagehttps://doi.org/10.1002/anie.201810261call_made
313
[1,3]‐Sigmatropic Shift of an Allylic Chloride
J. Boshkow, T. Scattolin, F. Schoenebeck, E.M. Carreira, Helv. Chim. Acta. 2018, 101, e18001.
external pagehttps://doi.org/10.1002/hlca.201800148call_made
312
Total Synthesis of (–)-Mitrephorone A
M.J.R. Richter, M. Schneider, M. Brandstätter, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc., 2018, 140, 16704–16710.
external pagehttp://dx.doi.org/10.1021/jacs.8b09685call_made
311
Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high
A. Chicca, M.A. Schafroth, I. Reynoso-Moreno, R. Erni, V. Petrucci, E.M. Carreira, J. Gertsch, Sci. Adv. 2018, 4, 1-10.
external pagehttp://dx.doi.org/10.1126/sciadv.aat2166call_madeexternal pagecall_made
310
Identification of biologically active δ-lactone eicosanoids as paraoxonase substrates
J.F. Teiber, J. Xiao, G.L. Kramer, S. Ogawa, C. Ebner, H. Wolleb, E.M. Carreira, D.M. Shih, R.W. Haley, Biochem. Biophys. Res. 2018, 505, 87–92
external pagehttps://doi.org/10.1016/j.bbrc.2018.09.083call_made
309
Total Synthesis of Epicolactone
A. G. Kravina, E.M. Carreira, Angew. Chem. Int. Ed. 2018, 57, 13159–13162
external pagehttp://dx.doi.org/10.1002/anie.201807709call_made
308
Unconventional Rose Odorants: Serendipitous Discovery and Unique Olfactory Properties of 2,2-Bis(prenyl)-3-oxobutyronitrile and Its Derivatives
N. Hauser, P. Kraft, E.M. Carreira, Synthesis 2018, 50,4490–4500.
external pagehttp://dx.doi.org/10.1055/s-0037-1610199call_made
307
Trimethyl Orthoacetate and Ethylene Glycol Mono-Vinyl Ether as Enolate Surrogates in Enantioselective Iridium-Catalyzed Allylation
Y. Sempere, E.M. Carreira, Angew. Chem. Int. Ed., 2018, 57, 7654–7658.
external pagehttp://dx.doi.org/10.1002/anie.201803558call_made
306
Synthesis and Structure–Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues
H. Wolleb, S. Ogawa, M. Schneider, A. Shemet, J. Muri, M. Kopf, E.M. Carreira, Org. Lett., 2018, 20, 3014−3016.
external pagehttp://dx.doi.org/10.1021/acs.orglett.8b01042call_made
305
HATRIC-based identification of receptors for orphan ligands
N. Sobotzki, M.A. Schafroth, A. Rudnicka, A. Koetemann, F. Marty, S. Goetze, Y. Yamauchi, E.M Carreira, B. Wollscheid, Nat. Comm. 2018, 9, 1519.
external pagehttp://dx.doi.org/10.1038/s41467-018-03936-zcall_made
304
Apoc Social: A Mobile Interactive and Social Learning Platform for Collaborative Solving of Advanced Problems in Organic Chemistry
N. Sievertsen, E.M. Carreira, Chimia, 2018, 72, 43–47.
external pagehttps://doi.org/10.2533/chimia.2018.43call_made
303
Allenylic Carbonates in Enantioselective Iridium-Catalyzed Alkylations
D.A. Petrone, M. Isomura, I. Franzoni, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2018, 140, 4697–4704.
external pagehttp://dx.doi.org/10.1021/jacs.8b01416call_made
302
Natural Products Synthesis: A Personal Retrospective and Outlook
E.M. Carreira, Isr. J. Chem. 2018, 58, 114–121.
external pagehttp://dx.doi.org/10.1002/ijch.201700127call_made
301
Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells
M. Soethoudt, S.C. Stolze, M.V. Westphal, L. van Stralen, A. Martella, E.J. van Rooden, W. Guba, Z.V. Varga, H. Deng, S.I. van Kasteren, U. Grether, A.P. IJzerman, P. Pacher, E.M. Carreira, H.S. Overkleeft, A. Ioan-Facsinay, L.H. Heitman, M. van der Stelt, J. Am. Chem. Soc., 2018, 140, 6067–6075.
external pagehttp://dx.doi.org/10.1021/jacs.7b11281call_made
300
Total Synthesis of (+)-Sarcophytin
L.J. Nannini, Suren J.Nemat, E.M. Carreira, Angew. Chem. Int. Ed., 2018, 130, 831–834.
external pagehttp://dx.doi.org/10.1002/anie.201711372call_made
299
Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling
M.V. Westphal, M.A. Schafroth, R.C. Sarott, M.A. Imhof, C.P. Bold, P. Leippe, A. Dhopeshwarkar, J.M. Grandner, V. Katritch, K. Mackie, D. Trauner, E.M. Carreira, J.A. Frank, J. Am. Chem. Soc. 2017, 139, 18206–18212.
external pagehttp://dx.doi.org/10.1021/jacs.7b06456call_made
298
Total Synthesis of (−)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution
A. Shemet, E.M. Carreira, Org. Lett. 2017, 19, 5529-5532.
external pagehttp://dx.doi.org/10.1021/acs.orglett.7b02619call_made
297
Total Synthesis and Stereochemical Assignment of (+)-Broussonetine H
S.L. Rössler, B.S. Schreib, M. Ginterseder, J.Y. Hamilton, E.M. Carreira, Org. Lett. 2017, 19, 5533–5536.
external pagehttp://dx.doi.org/10.1021/acs.orglett.7b02620call_made
296
Stereochemistry and biological activity of chlorinated lipids: a study of danicalipin A and selected diastereomers
J. Boshkow, S. Fischer, A.M. Bailey, S. Wolfrum, E.M. Carreira, Chem. Sci. 2017, 8, 6904-6910.
external pagehttp://dx.doi.org/10.1039/C7SC03124Fcall_made
295
Stereoselective Synthesis of Piperidines via Iridium-Catalyzed Cyclocondensation
T. Sandmeier, S.Krautwald, E.M. Carreira, Angew. Chem. Int. Ed. 2017, 56, 11515–11519.
external pagehttp://dx.doi.org/10.1002/anie.201706374call_made
294
Total Synthesis of (+)-Dendrowardol C
H. Wolleb, E.M. Carreira, Angew. Chem. Int. Ed. 2017, 56, 10890–10893.
external pagehttp://dx.doi.org/10.1002/anie.201705809call_made
293
Enantio- and Diastereoselective Spiroketalization Catalyzed by Chiral Iridium Complex
J.Y. Hamilton, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 8082–8085.
external pagehttp://dx.doi.org/10.1021/jacs.7b02856call_made
292
Enantioselective Iridium-Catalyzed Allylic Cyclizations
M.A. Schafroth, S.M. Rummelt, D. Sarlah, E.M. Carreira, Org. Lett. 2017, 19, 3235–3238.
external pagehttp://dx.doi.org/10.1021/acs.orglett.7b01346call_made
291
Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis
M. Hönig, P. Sondermann, N. Turner, E.M. Carreira, Angew. Chem. Int. Ed. 2017, 56, 8942–8973.
external pagehttp://doi.org/10.1002/anie.201612462call_made
290
Cyclopropanation Strategies in Recent Total Syntheses
C. Ebner and E.M. Carreira, Chem. Rev. 2017, 117, 11651–11679.
external pagehttp://dx.doi.org/10.1021/acs.chemrev.6b00798call_made
289
Oxetanyl Amino Acids for Peptidomimetics
G.P. Möller, S. Müller, B.T. Wolfstädter, S. Wolfrum, D. Schepmann, B. Wünsch, E.M. Carreira, Org. Lett. 2017, 19, 2510–2513.
external pagehttp://dx.doi.org/10.1021/acs.orglett.7b00745call_made
288
Stereodivergence in Asymmetric Catalysis
S. Krautwald and E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 5627–5639.
external pagehttp://dx.doi.org/10.1021/jacs.6b13340call_made
287
Study of Intermediates in Iridium–(Phosphoramidite,Olefin)-Catalyzed Enantioselective Allylic Substitution
S.L. Rössler, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 3603–3606.
external pagehttp://dx.doi.org/10.1021/jacs.6b12421call_made
286
Aqueous Instability of δ-Fluorobutylpiperidines
R. Vorberg, E.M. Carreira, K. Müller ChemMedChem 2017, 12, 431–437.
external pagehttp://dx.doi.org/10.1002/cmdc.201700027call_made
285
Partially fluorinated alkoxy groups − Conformational adaptors to changing environments
Q. A. Huchet, N. Trapp, B. Kuhn, B. Wagner, H. Fischer, N.A. Kratochwil, E.M. Carreira, K. Müller, J. Fluorine Chem. 2017, 198, 34–46.
external pagehttp://dx.doi.org/10.1016/j.jfluchem.2017.02.003call_made
284
Bicyclo[3.2.0]heptane as a Core Structure for Conformational Locking of 1,3-Bis-Pharmacophores, Exemplified by GABA
R. Vorberg, E.M. Carreira, K. Müller, Chem. Eur. J. 2017, 23, 3126–3138.
external pagehttp://dx.doi.org/10.1002/chem.201605179call_made
283
Synthesis of Phytocannabinoids
M.A. Schafroth, E.M. Carreira. In Phytocannabinoids; A. D. Kinghorn, H. Falk, S. Gibbons, J. Kobayashi, Eds.; Progress in the Synthesis of Organic Natural Products Series 103; Springer: Switzerland, 2017; pp 37–59.
external pagehttp://doi.org/10.1007/978-3-319-45541-9_2call_made
282
Enantioselective Addition of Alkynes to α,α-Dichlorinated Aldehydes
Y. Sempere Molina, J. Ruchti, E.M. Carreira, Org. Lett. 2017, 19, 743–745.
external pagehttp://doi.org/10.1021/acs.orglett.6b03692call_made
281
Structural and Conformational Aspects of Equatorial and Axial Trifluoromethyl, Difluoromethyl, and Monofluoromethyl Groups
Q. A. Huchet, W. B. Schweizer, B. Kuhn, E.M. Carreira, K. Müller, Chem. Eur. J. 2016, 22, 16920–16928.
external pagehttp://doi.org/10.1002/chem.201602643call_made
280
Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.
R. Vorberg, N. Trapp, D. Zimmerli, B. Wagner, H. Fischer, N.A. Kratochwil, M. Kansy, E.M. Carreira, K. Müller, ChemMedChem 2016, 11, 2216–2239.
external pagehttp://doi.org/10.1002/cmdc.201600325call_made
279
Rh-Catalyzed Stereospecific Synthesis of Allenes from Propargylic Benzoates and Arylboronic Acids
J. Ruchti, E.M. Carreira, Org. Lett. 2016, 18, 2174–2176.
external pagehttp://doi.org/10.1021/acs.orglett.6b00793call_made
278
Bioisosteric Exchange of Csp3-Chloro and Methyl Substituents: Synthesis and Initial Biological Studies of Atpenin A5 Analogues
S. Krautwald, C. Nilewski, M. Mori, K. Shiomi, S. Ōmura, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 4049–4053.
external pagehttp://doi.org/10.1002/anie.201511672call_made
277
Synthesis and Biological Evaluation of Bromo- and Fluorodanicalipin A.
S. Fischer, N. Huwyler, S. Wolfrum, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 2555–2558.
external pagehttp://dx.doi.org/10.1002/anie.201510608call_made
276
Formation of α-SF5-Enolate Enables Preparation of 3-SF5-Quinolin-2-ones, 3-SF5-Quinolines, and 3-SF5-Pyridin-2-ones: Evaluation of their Physicochemical Properties.
A. Joliton, J.-M. Plancher, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 2113–2117.
external pagehttp://dx.doi.org/10.1002/anie.201510380call_made
275
A Unified Strategy to Plakortin Pentalenes: Total Syntheses of (±)-Gracilioethers E and F.
S.A. Ruider and E.M. Carreira, Org. Lett. 2016, 18, 220–223.
external pagehttp://dx.doi.org/10.1021/acs.orglett.5b03356call_made
274
Biological Investigations of (+)-Danicalipin A Enabled Through Synthesis.
A.M. Bailey, S. Wolfrum, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 639.
external pagehttp://dx.doi.org/10.1002/anie.201509082call_made
273
Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.
Q.A. Huchet, B. Kuhn, B. Wagner, N.A. Kratochwil, H. Fischer, M. Kansy, D. Zimmerli, E.M. Carreira, and K. Müller, Journal of Medicinal Chemistry 2015, 58, 9041.
external pagehttp://dx.doi.org/10.1021/acs.jmedchem.5b01455call_made
272
Synthesis and Biological Evaluation of Chlorinated Analogs of Leukotoxin Diol.
C. Nilewski, C. Le Chapelain, S. Wolfrum, E.M. Carreira, Org. Lett. 2015, 17,5602.
external pagehttp://dx.doi.org/10.1021/acs.orglett.5b02814call_made
271
Stereodivergent Dual Catalytic α-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes.
T. Sandmeier, S. Krautwald, H.F. Zipfel, E.M. Carreira, Angew. Chem. Int. Ed. 2015, 54, 14363.
external pagehttp://dx.doi.org/10.1002/anie.201506933call_made
270
Total Synthesis of Prostaglandin 15d-PGJ2 and Investigation of its Effect on the Secretion of IL-6 and IL-12.
J. Egger, S. Fischer, P. Bretscher, S. Freigang, M. Kopf, E.M. Carreira, Org. Lett. 2015, 17, 4340.
external pagehttp://dx.doi.org/10.1021/acs.orglett.5b02181call_made
269
Pentafulvene for the Synthesis of Complex Natural Products: Total Syntheses of (±)-Pallambins A and B.
C. Ebner, E.M. Carreira, Angew. Chem. Int. Ed. 2015, 54, 11227.
external pagehttp://dx.doi.org/10.1002/anie.201505126call_made
268
A Unified Strategy to 6-5-6-5-6 Membered Epipolythiodiketopiperazines: Studies towards the Total Synthesis of Scabrosin Diacetate and Haematocin.
H.F. Zipfel, E.M. Carreira, Chem. Eur. J. 2015, 21, 12475.
external pagehttp://dx.doi.org/10.1002/chem.201500918call_made
267
Addition of Trifluoroborates Oxetanyl N,O-Acetals: Entry into Spiro and Fused Saturated Heterocycles.
P.B. Brady, E.M. Carreira, Org. Lett. 2015, 17, 3350.
external pagehttp://dx.doi.org/10.1021/acs.orglett.5b01607call_made
266
Iridium-Catalyzed Enantioselective Allylic Alkylation with Functionalized Organozinc-Bromides.
J.Y. Hamilton, D. Sarlah, E.M. Carreira, Angew. Chem. Int. Ed. 2015, 54, 7644.
external pagehttp://dx.doi.org/10.1002/anie.201501851call_made
265
Total Synthesis of Gelsemoxonine through a Spirocyclopropane Isoxazolidine Ring Contraction.
S. Diethelm, E.M. Carreira, J. Am. Chem. Soc. 2015, 137, 6084.
external pagehttp://dx.doi.org/10.1021/jacs.5b02574call_made
264
Formaldehyde N,N-Dialkylhydrazones as Neutral Formyl Anion Equivalents in Iridium-Catalyzed Asymmetric Allylic Substitution.
S. Breitler, E.M. Carreira, J. Am. Chem. Soc. 2015, 137, 5296.
external pagehttp://dx.doi.org/10.1021/jacs.5b01951call_made
263
Stereochemical Studies of the Opening of Chloro Vinyl Epoxides: Cyclic Chloronium Ions as Intermediates.
A. Shemet, D. Sarlah, E.M. Carreira, Org. Lett. 2015, 17, 1878.
external pagehttp://dx.doi.org/10.1021/acs.orglett.5b00558call_made
262
Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.
P. Bretscher, J. Egger, A. Shamshiev, M. Trötzmüller, H. Köfeler, E.M. Carreira, M. Kopf, S. Freigang, EMBO Mol Med 2015, 7, 593.
external pagehttp://dx.doi.org/10.15252/emmm.201404702call_made
261
Novel SF5-Anilines and SF5-Aryl Ethers from SF5-Substituted Potassium Aryl Trifluoroborates.
A. Joliton, E.M. Carreira, Synlett 2015, 26, 737.
external pagehttp://dx.doi.org/10.1055/s-0034-1379981call_made
260
Evaluation of tert-Butyl Isosteres: Case Studies of Physicochemical and Pharmacokinetic Properties, Efficacies, and Activities.
M.V. Westphal, B. T. Wolfstädter, J.-M. Plancher, J. Gatfield, E.M. Carreira, ChemMedChem 2015, 10, 461.
external pagehttp://dx.doi.org/10.1002/cmdc.201402502call_made
259
Iridium-Catalyzed Enantioselective Allylic Vinylation with Potassium Alkenyltrifluoroborates.
J.Y. Hamilton, D. Sarlah, E.M. Carreira, Org. Synth. 2015, 92, 1.
external pagehttp://dx.doi.org/10.15227/orgsyn.092.0001call_made
258
Discovery of a Highly Potent Anti-inflammatory Epoxyisoprostane-Derived Lactone.
J. Egger, P. Bretscher, S. Freigang, M. Kopf, E.M. Carreira, J. Am. Chem. Soc. 2014, 136, 17382.
external pagehttp://dx.doi.org/10.1021/ja509892ucall_made
257
Total Synthesis of (±)-Hippolachnin A.
S.A. Ruider, T. Sandmeier, E.M. Carreira, Angew. Chem. Int. Ed. 2014, 53, 2378.
external pagehttp://dx.doi.org/10.1002/anie.201410419call_made
256
Ir-Catalyzed Reverse Prenylation of 3-Substituted Indoles: Total Synthesis of (+)-Aszonalenin and (−)-Brevicompanine B.
J. Ruchti, E.M. Carreira, J. Am. Chem. Soc. 2014, 136, 16756.
external pagehttp://dx.doi.org/10.1021/ja509893scall_made
255
Stereodivergent Total Synthesis of Δ9-Tetrahydrocannabinols.
M.A. Schafroth, G. Zuccarello, S. Krautwald, D. Sarlah, E.M. Carreira, Angew. Chem. Int. Ed. 2014, 53, 13898.
external pagehttp://dx.doi.org/10.1002/anie.201408380call_made
254
Iridium-Catalyzed Enantioselective Allyl–Allylsilane Cross-Coupling.
J.Y. Hamilton, N. Hauser, D. Sarlah, E.M. Carreira, Angew. Chem. Int. Ed. 2014, 53, 10759.
external pagehttp://dx.doi.org/10.1002/anie.201406077call_made
253
Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry.
M. McLaughlin, R. Yazaki, T.C. Fessard, E.M. Carreira, Org. Lett. 2014, 16, 4070.
external pagehttp://dx.doi.org/10.1021/ol501590ncall_made
252
Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities.
E.M. Carreira, T.C. Fessard, Chem. Rev. 2014, 114, 8257.
external pagehttp://dx.doi.org/10.1021/cr500127bcall_made
251
An Efficient Synthesis Strategy to the Core Structure of 6–5–6–5–6-Membered Epipolythiodiketopiperazines.
H.F. Zipfel, E.M. Carreira, Org. Lett. 2014, 16, 2854.
external pagehttp://dx.doi.org/10.1021/ol500990fcall_made
250
Mechanistic Insight into the Spirocyclopropane Isoxazolidine Ring Contraction.
S. Diethelm, F. Schoenebeck, E.M. Carreira, Org. Lett. 2014, 16, 960.
external pagehttp://dx.doi.org/10.1021/ol403693tcall_made
249
Efficient Synthesis Strategies by Application of Transition Metal-Catalyzed Carbene/Nitrene Insertions into C–H Bonds.
J. Egger, E.M. Carreira, Nat. Prod. Rep. 2014, 31, 449.
external pagehttp://dx.doi.org/10.1039/C3NP70084Dcall_made
248
Stereodivergent α-Allylation of Linear Aldehydes with Dual Iridium and Amine Catalysis.
S. Krautwald, M.A. Schafroth, D. Sarlah, E.M. Carreira, J. Am. Chem. Soc. 2014, 136, 3020.
external pagehttp://dx.doi.org/10.1021/ja5003247call_made
247
Iridium-Catalyzed Enantioselective Allyl–Alkene Coupling.
J.Y. Hamilton, D. Sarlah, E.M. Carreira, J. Am. Chem. Soc. 2014, 136, 3006.
external pagehttp://dx.doi.org/10.1021/ja412962wcall_made
246
Autotandem Catalysis with Ruthenium: Remote Hydroesterification of Allylic Amides.
N. Armanino, M. Lafrance, E.M. Carreira, Org. Lett. 2014, 16, 572.
external pagehttp://dx.doi.org/10.1021/ol4034463call_made