Recent Publications
388
Enantiospecific Synthesis of α-Tertiary Amines: Ruthenium-Catalyzed Allylic Amination with Aqueous Ammonia
S. M. Papidocha, H. R. Wilke, K. J. Patej, M. Isomura, T. J. Stucky, L. Rothenbühler, E. M. Carreira, J. Am. Chem. Soc. 2025, ASAP.

387
Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome
L. Lüthy, L. G. S. Thies, K. N. Beitl, M. Hansen, J. McManus, M. Afzal, L. Schrangl, S. Bloch, G. Subbiahdoss, E. Reimhult, C. Schäffer, E. M. Carreira, ACS Cent. Sci. 2025, ASAP.

386
Ligand Influence on the Performance of Cesium Lead Bromide Perovskite Quantum Dots in Photocatalytic C(sp³)–H Bromination Reactions
W. M. Amberg, H. Lindner, Y. Sahin, E. Staudinger, V. Morad, S. Sabisch, L. G. Feld, Y. Li, D. N. Dirin, M. V. Kovalenko, E. M. Carreira, J. Am. Chem. Soc. 2025, 147, 8548-8558.

385
Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe
E. M. Carreira, M. Kosar, T. Perera, R. L. Z. Ganzoni, R. C. Sarott, L. Borrega-Roman, R. M. Vitale, A. Ligresti, A. Rufer, W. Guba, U. Grether, D. Veprintsev, D. Sykes, Angew. Chem. Int. Ed. 2025, e202421885.

384
Probing Native CB2 Receptor Mobility in Plasma Membranes of Living Cells by Fluorescence Recovery After Photobleaching
F. Ciaramellano, A. Leuti, A. D. E. Kurtz, R. Sarott, M. Westphal, P. Pfaff, U. Grether, E. M. Carreira, M. Maccarrone, S. Oddi, ChemBioChem 2025, e202400921.
383
Photo- and Cobalt-Catalyzed Cycloisomerization of Unsaturated Guanidines, (Iso-)Ureas, and Carbonates
H. Lindner, E. M. Carreira, Org. Lett. 2025, 27, 704–708.
external page https://pubs.acs.org/doi/10.1021/acs.orglett.4c04695

382
Construction of Vicinal Quaternary Centers via Ru-Catalyzed Enantiospecific Allylic Substitution with Lithium Ester Enolates
S. M. Papidocha, E. M. Carreira, J. Am. Chem. Soc. 2024, 146, 23674–23679.

381
Synthesis of Primary Amines via Hydrogen Atom Transfer-Initiated Cyclization/Reduction Cascade of Unsaturated Nitriles
H. Lindner, M. Schneider, P. Mader, F. Su, E. M. Carreira, Org. Lett. 2024, 26, 5467–5471.
external page https://pubs.acs.org/doi/10.1021/acs.orglett.4c01739

380
Patent review of cannabinoid receptor type 2 (CB2R) modulators (2016-present)
M. Kosar, L. Mach, E. M. Carreira, M. Nazaré, P. Pacher, U. Grether, Expert Opinion on Therapeutic Patents 2024
379
Cobalt-Catalyzed Photo-Semipinacol Rearrangement of Unactivated Allylic Alcohols
H. Lindner, E. M. Carreira, Angew. Chem. Int. Ed. 2024, e202407827.
external page https://onlinelibrary.wiley.com/doi/10.1002/anie.202407827

378
Aryl Azocyclopropeniums: Minimalist, Visible-Light Photoswitches
M. Fink, J. Stäuble, M. Weisgerber, E. M. Carreira, J. Am. Chem. Soc. 2024, 146, 9519–9525.

377
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
M. Kosar, R. C. Sarott, D. A. Sykes, A. E. G. Viray, R. M. Vitale, N. Tomašević, X. Li, R. L. Z. Ganzoni, B. Kicin, L. Reichert, K. J. Patej, U. Gómez-Bouzó, W. Guba, P. J. McCormick, T. Hua, C. W. Gruber, D. B. Veprintsev, J. A. Frank, U. Grether, E. M. Carreira, ACS Cent. Sci. 2024, 10, 956–968.
external page https://pubs.acs.org/doi/10.1021/acscentsci.3c01461

376
Photo- and Cobalt-Catalyzed Synthesis of Heterocycles via Cycloisomerization of Unactivated Olefins
H. Lindner, W. M. Amberg, T. Martini, D. M. Fischer, E. Moore, E. M. Carreira, Angew. Chem. Int. Ed. 2024, e202319515.
external page https://onlinelibrary.wiley.com/doi/10.1002/anie.202319515

375
Harnessing PROTAC technology to combat stress hormone receptor activation
M. Gazorpak, K. M. Hugentobler, D. Paul, P.-L. Germain, M. Kretschmer, I. Ivanova, S. Frei, K. Mathis, R. Rudolf, S. M. Barrenechea, V. Fischer, X. Xue, A. L. Ptaszek, J. Holzinger, M. Privitera, A. Hierlemann, O. C. Meijer, R. Konrat, E. M. Carreira, J. Bohacek & K. Gapp, Nat. Commun. 2023, 14, 8177.
external page https://www.nature.com/articles/s41467-023-44031-2
374
A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging
C. Thomas, R. Erni, J. Y. Wu, F. Fischer, G. Lamers, G. Grigolon, S. J. Mitchell, K. Zarse, E. M. Carreira & M. Ristow, Nat. Commun. 2023, 14, 8142.
external page https://www.nature.com/articles/s41467-023-43672-7
373
Total Synthesis of (+)-Euphorikanin A via an Atropospecific Cascade
M. J. Classen, B. Kicin, V. A. P. Ruf, A. Hamminger, L. Ribadeau-Dumas, W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc. 2023, ASAP.

372
Iron-Mediated Photochemical Anti-Markovnikov Hydroazidation of Unactivated Olefins
H. Lindner, W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc. 2023, 145, 22347–22353.
external page https://pubs.acs.org/doi/full/10.1021/jacs.3c09122

371
Enantioselective Total Syntheses of Cassane Furanoditerpenoids and Their Stimulation of Cellular Respirationin Brown Adipocytes
H. H. Bulthaupt, F. Glatz, S. M. Papidocha, C. Wu, S. Teh, S. Wolfrum, L. Balážová, C. Wolfrum, E. M. Carreira, J. Am. Chem. Soc. 2023, 145, 21562–21568.

370
Synthesis of Neocaesalpin A, AA, and Nominal Neocaesalpin K
S. M. Papidocha, H. H. Bulthaupt, E. M. Carreira, Angew. Chem. Int. Ed. 2023, e202310149.

369
Cobalt-Catalyzed Aerobic Aminocyclization of Unsaturated Amides for the Synthesis of Functionalized γ- and δ-Lactams
M. Freis, M. Balkenhohl, D. M. Fischer, T. Georgiev, R. C. Sarott, E. M. Carreira, Org. Lett. 2023, 25, 6380–6384.

368
Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells
M. Kosar, D. A. Sykes, A. E. G. Viray, R. M. Vitale, R. C. Sarott, R. L. Ganzoni, D. Onion, J. M. Tobias, P. Leippe, C. Ullmer, E. A. Zirwes, W. Guba, U. Grether, J. A. Frank, D. B. Veprintsev, E. M. Carreira, J. Am. Chem. Soc., 2023, 145, 15094–15108.

367
Organophotocatalytic carbo-heterofunctionalization of unactivated olefins with pendant nucleophiles
D. M. Fischer, M. Freis, W. M. Amberg, H. Lindner, E. M. Carreira, Chem. Sci., 2023, 14, 7256-726.

366
Enantioselective Total Synthesis of (+)-Pedrolide
M. Fadel, E. M. Carreira, J. Am. Chem. Soc., 2023, 145, 8332–8337.

365
Role of Noncovalent Interactions in Inducing High Enantioselectivity in an Alcohol Reductive Deoxygenation Reaction Involving a Planar Carbocationic Intermediate
S. Ghosh, A. Changotra, D. A. Petrone, M. Isomura, E. M. Carreira, R. B. Sunoj, J. Am. Chem. Soc., 2023, 145, 2884–2900.
364
Conformational Diversity in Partially Fluorinated N-Alkyl Pipecolic Acid Amide Derivatives
N. Trapp, M. Wörle, B. Kuhn, P. Gerber, R. Vorberg, E. M. Carreira, K. Müller, Helv. Chim. Acta, 2023, 106, e202200146.
363
Intermolecular Organophotocatalytic Cyclopropanation of Unactivated Olefins
D. M. Fischer, H. Lindner, W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc., 2023, 145, 774–780.

362
Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium
R. Ueoka, P. Sondermann, S. Leopold-Messer, Y. Liu, R. Suo, A, Bhushan, L. Vadakumchery, U. Greczmiel, Y. Yashiroda, H. Kimura, S. Nishimura, Y. Hoshikawa, M. Yoshida, A. Oxenius, S. Matsunaga, R. T. Williamson, E. M. Carreira, J. Piel, Nat. Chem., 2022, 14, 1193–1201.
361
Enantioselective Total Synthesis of (+)-Aberrarone
W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc., 2022, 144, 15475–15479.

360
Carbon Nitride Photoredox Catalysis Enables the Generation of the Dioxolanyl Radical for Conjugate Addition Reactions
V. C. Gerken, E. M. Carreira, ACS Catal., 2022, 12, 10787–10792.

359
Ritter reaction for the synthesis of picolinamides
B. S. Schreib, J. Margarini, E. M. Carreira, Tetrahedron, 2022, 132937.

358
Reverse-Design toward Optimized Labeled Chemical Probes – Examples from the Endocannabinoid System
M. Guberman, M. Kosar, A. Omran, E. M. Carreira, M. Nazaré, U. Grether, Chimia, 2022, 76, 425-434.
357
Total Synthesis of Mutanobactins A, B from the Human Microbiome: Macrocyclization and Thiazepanone Assembly in a Single-Step
M. E. Hansen, S. O. Yasmin, S. Wolfrum, E. M. Carreira, Angew. Chem. Int. Ed., 2022, e202203051.

356
Cobalt-Catalyzed Cyclization of Unsaturated N-Acyl Sulfonamides: a Diverted Mukaiyama Hydration Reaction
D. M. Fischer, M. Balkenhohl, E. M. Carreira, JACS Au, 2022, 2, 1071–1077.

355
Picolinamides and Iodoalkynes Enable Palladium-Catalyzed syn-Aminoalkynylation of Di- and Trisubstituted Alkenes to Give Pyrrolidines
N. Müller, B. S. Schreib, S. U. Leutenegger, E. M. Carreira, Angew. Chem. Int. Ed., 2022, e202204535.

354
Detection of Cannabinoid Receptor Type 2 in Native Cells and Zebrafish with a Highly Potent, Cell-Permeable Fluorescent Probe
T. Gazzi, B. Brennecke, K. Atz, C. Korn, D. Sykes, G. Forn-Cuni, P. Pfaff, R. C. Sarott, M. V. Westphal, Y. Mostinski, L. Mach, M. Wasinska-Kalwa, M. Weise, B. L. Hoare, T. Miljuš, M. Mexi, N. Roth, E. J. Koers, W. Guba, A. Alker, A. C. Rufer, E. A. Kusznir, S. Huber, C. Raposo, E. A. Zirwes, A. Osterwald, A. Pavlovic, S. Moes, J. Beck, M. Nettekoven, I. Benito-Cuesta, T. Grande, F. Drawnel, G. Widmer, D. Holzer, T. van der Wel, H. Mandhair, M. Honer, J. Fingerle, J. Scheffel, J. Broichhagen, K. Gawrisch, J. Romero, C. J. Hillard, Z. V. Varga, M. van der Stelt, P. Pacher, J. Gertsch, C. Ullmer, P. J. McCormick, S. Oddi, H. Spaink, M. Maccarrone, D. Veprintsev, E. M. Carreira, U. Grether, M. Nazare , Chem. Sci., 2022, 13, 5539-5545.
354
Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan
G. Grigolon, E. Araldi, R. Erni, J. Y. Wu, C.Thomas, M. La Fortezza, B. Laube, D. Pöhlmann, M. Stoffel, K. Zarse, E. M. Carreira, M. Ristow, F. Fischer, Nat. Commun., 2022, 13, 107 .
353
Total Synthesis of Shearinines D and G: A Convergent Approach to Indole Diterpenoids
N. Hauser, M. A. Imhof, S. S. Eichenberger, T. Kündig, E. M. Carreira, Angew. Chem. Int. Ed., 2022, 61, e202112838.

352
Allene C(sp2)–H Activation and Alkenylation Catalyzed by Palladium
B. S. Schreib, M. Son, F. A. Aouane, M.-H. Baik, E. M. Carreira, J. Am. Chem. Soc., 2021, 143, 21705–21712.

351
Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks
M. Müller, F. Gräbnitz, N. Barandun, Y. Shen, F. Wendt, S. N. Steiner, Y. Severin, S. U. Vetterli, M. Mondal, J. R. Prudent, R. Hofmann, M. van Oostrum, R. C. Sarott, A. I. Nesvizhskii, E. M. Carreira, J. W. Bode, B. Snijder, J. A. Robinson, M. J. Loessner, A. Oxenius, B. Wollscheid, Nat. Commun., 2021, 12, 7036.
350
Azoacetylenes for the Synthesis of Arylazotriazole Photoswitches
P. Pfaff, F. Anderl, M. Fink, M. Balkenhohl, E. M. Carreira, J. Am. Chem. Soc, 2021, 143, 14495–14501.

349
Δ9-cis-Tetrahydrocannabinol: Natural Occurrence, Chirality, and Pharmacology
M. A. Schafroth, G. Mazzoccanti, I. Reynoso-Moreno, R. Erni, F. Pollastro, D. Caprioglio, B. Botta, G. Allegrone, G. Grassi, A. Chicca, F. Gasparrini, J. Gertsch, E. M. Carreira, G. Appendino, J. Nat. Prod., 2021, 84, 2502–2510.

348
Mutanobactin D from the Human Microbiome: Total Synthesis, Configurational Assignment, and Biological Evaluation
F. Pultar, M. E. Hansen, S. Wolfrum, L. Böselt, R. Fróis-Martins, S. Bloch, A. G. Kravina, D. Pehlivanoglu, C. Schäffer, S. LeibundGut-Landmann, S. Riniker, E. M. Carreira, J. Am. Chem. Soc., 2021, 143, 10389–10402.

347
Mn- and Co-Catalyzed Aminocyclizations of Unsaturated Hydrazones Providing a Broad Range of Functionalized Pyrazolines
M. Balkenhohl, S. Kölbl, T. Georgiev, E. M. Carreira, JACS Au, 2021, 1, 919–924.

346
Enantioselective Total Synthesis of (+)-Euphorikanin A
M. J. Classen, M. N. A. Böcker, R. Roth, W. M. Amberg, E. M. Carreira, J. Am. Chem. Soc., 2021, 143, 8261–8265.

345
Enantio- and Chemoselective Intramolecular Iridium-Catalyzed O-Allylation of Oximes
T. Sandmeier, E. M. Carreira, Org. Lett., 2021, 23, 2643–2647.

344
Construction of Vicinal Quaternary Centers via Iridium-Catalyzed Asymmetric Allenylic Alkylation of Racemic Tertiary Alcohols
M. Isomura, D. A. Petrone, E. M. Carreira, J. Am. Chem. Soc., 2021, 143, 3323–3329.

343
Enantioselective Synthesis of Cyclic Nitrones by Chemoselective Intramolecular Allylic Alkylation of Oximes
T. Sandmeier, E. M. Carreira, Angew. Chem. Int. Ed., 2021, 60, 9913– 9918.

342
Discovery and Surprises with Cyclizations, Cycloadditions, Fragmentations, and Rearrangements in Complex Settings
K. M. Hugentobler, E. M. Carreira, Acc. Chem. Res., 2021, 54, 890–902.

341
Optical Control of Cannabinoid Receptor 2‑Mediated Ca2+ Release Enabled by Synthesis of Photoswitchable Probes
R. C. Sarott, A. E. G. Viray, P. Pfaff, A. Sadybekov, G. Rajic, V. Katritch, E. M. Carreira, J. A. Frank, J. Am. Chem. Soc., 2021, 143, 736–743.

340
Modern Catalytic Enantioselective Approaches to Piperidines
T. Sandmeier, E. M. Carreira. In Synthetic Approaches to Nonaromatic Nitrogen Heterocycles; A. M. M. M. Faisca Phillips, Ed.; John Wiley & Sons, Inc.: Hoboken, New Jersey, 2010; pp 249–271.
339
Total Synthesis of (−)-Mitrephorone A Enabled by Stereoselective Nitrile Oxide Cycloaddition and Tetrasubstituted Olefin Synthesis
M. Schneider, M. J. R. Richter, and E. M Carreira, J. Am. Chem. Soc., 2020, 142, 17802–17809.

338
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
R. C. Sarott, M. Westphal, P. Pfaff, C. Korn, D. A. Sykes, T. Gazzi, B. Brennecke, K. Atz, M. Weise, Y. Mostinski, P. Hompluem, E. Koers, T. Miljus, N. J. Roth, H. Asmelash, M. C. Vong, J. Piovesan, W. Guba, A. Rufer, E. A.Kusznir, S. Huber, C. Raposo, E. A. Zirwes, A. Osterwald, A. Pavlovic, S. Moes, J. Beck, I. Benito-Cuesta, T. Grande, S. Ruiz de Martin, A. A. Yeliseev, F. Drawnel, G. Widmer, D. Holzer, T. van der Wel, H. Mandhair, C. Yuan, W. Drobyski, Y. Saroz, N. L. Grimsey, M. Honer, J. Fingerle, K. Gawrisch, J. Romero, C. Hillard, Z. Varga, M. van der Stelt, P. Pacher, J. Gertsch, P. McCormick, C. Ullmer, S. Oddi, M. Maccarrone, D. Veprintsev, M. Nazaré, U. Grether, and E. M Carreira, J. Am. Chem. Soc., 2020, 142, 16953–16964.

337
Activation of Copper Species on Carbon Nitride for Enhanced Activity in the Arylation of Amines
E. Vorobyeva, V. C. Gerken, S. Mitchell, A. Sabadell-Rendón, R. Hauert, S. Xi, A. Borgna, D. Klose, S. M. Collins, P. A. Midgley, D. M. Kepaptsoglou, Q. M. Ramasse, A. Ruiz-Ferrando, E. Fako, M. A. Ortuño, N. Lopez, E. M. Carreira, and J. Pérez-Ramírez, ACS Catal, 2020, 10, 11069–11080.

336
Ir‐Catalyzed Enantioconvergent Synthesis of Diversely Protected Allenylic Amines Employing Ammonia Surrogates
F. Glatz, D. A. Petrone, and E. M. Carreira, Angew. Chem. Int. Ed. 2020, 59, 16404–16408.

335
Derailed Ohira-Bestmann Reaction of γ,δ-Unsaturated Aldehydes for the Stereoselective Synthesis of Cyclopenta[c]pyrazoles
T. Sandmeier, N. Sievertsen, and E. M. Carreira, Helv. Chim. Acta 2020, 103, e2000058.

334
Ring-Fused Cyclobutanes via Cycloisomerization of Alkylidenecyclopropane Acylsilanes
S. Eichenberger, M. Hönig, M.J.R. Richter, R. Gershoni-Poranne, and E. M. Carreira, Chem. Sci., 2020, 11, 5294–5298.

333
The Serendipitous Discovery of a Rose Odorant
N. Hauser, P. Kraf, E. M. Carreira, Chimia 2020, 74, 247–251.
332
Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways
J. Muri, Q. Feng, H. Wolleb, A. Shamshiev, C. Ebner, L. Tortola, P. Broz, E. M. Carreira, M. Kopf, Cell Reports, 2020, 30, 4399–4417.
331
Molecular Recognition and Cocrystallization of Methylated and Halogenated Fragments of Danicalipin A by Enantiopure Alleno-Acetylenic Cage Receptors
C. Gropp, S. Fischer, T. Husch, N. Trapp, E. M. Carreira, F. Diederich, J. Am. Chem. Soc. 2020, 142, 4749–4755.
external page https://doi.org/10.1021/jacs.9b13217

330
Palladium-Catalyzed C–H Alkynylation of Unactivated Alkenes
B. S. Schreib, M. Fadel, E. M. Carreira, Angew. Chem. Int. Ed. 2020, 59, 7818 –7822.
external page https://doi.org/10.1002/anie.202000935

329
Highly Selective, Amine-Derived Cannabinoid Receptor 2 Probes
M. V. Westphal, R. C. Sarott, E. A. Zirwes, A. Osterwald, W. Guba, C. Ullmer, U. Grether, E. M. Carreira, Chem. Eur. J. 2020, 26, 1380–1387.
external page https://doi.org/10.1002/chem.201904584

328
Enantioselective Iridium-Catalyzed α-Allylation with Aqueous Solutions of Acetaldehyde
T. Sandmeier, E. M. Carreira, Org. Lett. 2020, 22, 1135–1138.
external page https://doi.org/10.1021/acs.orglett.9b04658

327
Total Synthesis and Structural Revision of a Harziane Diterpenoid
M. Hönig, E. M. Carreira, Angew. Chem. Int. Ed. 2020, 59, 1192–1196.
external page https://doi.org/10.1002/anie.201912982

326
The Catalytic, Enantioselective Favorskii Reaction: In Situ Formation of Metal Alkynylides and Their Additions to Aldehydes
Y. Sempere, E. M. Carreira, book chapter in S.E. Denmark et al., "Organic Reactions", Vol 100, Wiley, 2020.
external page https://doi.org/10.1002/0471264180.or100.04
325
Pyridinium Salts as Redox‐Active Functional Group Transfer Reagents
S.L. Rössler, B.J. Jelier, E. Magnier, G. Dagousset, E. M. Carreira, A. Togni, Angew. Chem. Int. Ed. 2020, 59, 9264–9280.
external page http://dx.doi.org/10.1002/anie.201911660

324
Asymmetric Synthesis of the Tricyclooctane Core of Trachylobane Natural Products and Related Terpenoids
M. Schneider, M. J. R. Richter, S. Krautwald, E. M. Carreira, Org. Lett. 2019, 21, 8705-8707.
external page https://doi.org/10.1021/acs.orglett.9b03303

323
Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs
P. Pfaff, K. T. G. Samarasinghe, C. M. Crews, E. M. Carreira, ACS Cent. Sci. 2019, 5, 1682-1690.
external page https://doi.org/10.1021/acscentsci.9b00713

322
Gold(I)-catalyzed stereoselective cyclization of 1,3-enyne aldehydes by a 1,3-acyloxy migration/Nazarov cyclization/aldol addition cascade
M. Brandstätter, N. Huwyler, E.M. Carreira, Chem. Sci. 2019, 10, 8219–8223 .
external page https://doi.org/10.1039/C9SC02828E

321
Iridium-Catalyzed Enantioselective Allylic Substitution with Aqueous Solutions of Nucleophiles
T. Sandmeier, F.W. Goetzke, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2019, 141, 12212–12218.
external page https://doi.org/10.1021/jacs.9b05830

320
Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands
S.L. Rössler, D.A. Petrone, E.M. Carreira, Acc. Chem. Res. 2019, 52, 2657–2672.
external page https://doi.org/10.1021/acs.accounts.9b00209

319
Stereochemical Revision, Total Synthesis, and Solution State Conformation of the Complex Chlorosulfolipid Mytilipin B
P. Sondermann, E.M. Carreira, J. Am. Chem. Soc. 2019, 141, 10510–10519.
external page https://doi.org/10.1021/jacs.9b05013

318
Morpholine Ketene Aminal as Amide Enolate Surrogate in Iridium‐Catalyzed Asymmetric Allylic Alkylation
Y. Sempere, J.L. Alfke, S.L. Rössler, E.M. Carreira, Angew. Chem. Int. Ed., 2019, 58, 9537–9541.
external page https://doi.org/10.1002/anie.201903090

317
Palladium-Catalyzed Regioselective C−H Iodination of Unactivated Alkenes
B.S. Schreib, E.M. Carreira, J. Am. Chem. Soc., 2019, 141, 8758–8763.
external page https://doi.org/10.1021/jacs.9b03998

316
Coordination-Induced Stereocontrol over Carbocations: Asymmetric Reductive Deoxygenation of Racemic Tertiary Alcohols
M. Isomura, D.A. Petrone, E.M. Carreira, J. Am. Chem. Soc., 2019, 141, 4738–4748.
external page https://doi.org/10.1021/jacs.9b00862

315
Total Synthesis of (–)-Merochlorin A
M. Brandstätter, M. Freis, N. Huwyler, E.M. Carreira, Angew. Chem. Int. Ed. 2019, 58, 2490–2494.
external page https://doi.org/10.1002/anie.201813090

314
Pyridyl Radical Cation for C–H Amination of Arenes
S.L. Rössler, B.J. Jelier, P.F. Tripet, A. Shemet, G. Jeschke, A. Togni, E.M. Carreira, Angew. Chem. Int. Ed. 2019, 131, 536 –541.
external page https://doi.org/10.1002/anie.201810261

313
[1,3]‐Sigmatropic Shift of an Allylic Chloride
J. Boshkow, T. Scattolin, F. Schoenebeck, E.M. Carreira, Helv. Chim. Acta. 2018, 101, e18001.
external page https://doi.org/10.1002/hlca.201800148
312
Total Synthesis of (–)-Mitrephorone A
M.J.R. Richter, M. Schneider, M. Brandstätter, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc., 2018, 140, 16704–16710.
external page http://dx.doi.org/10.1021/jacs.8b09685

311
Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high
A. Chicca, M.A. Schafroth, I. Reynoso-Moreno, R. Erni, V. Petrucci, E.M. Carreira, J. Gertsch, Sci. Adv. 2018, 4, 1-10.
external page http://dx.doi.org/10.1126/sciadv.aat2166external page

310
Identification of biologically active δ-lactone eicosanoids as paraoxonase substrates
J.F. Teiber, J. Xiao, G.L. Kramer, S. Ogawa, C. Ebner, H. Wolleb, E.M. Carreira, D.M. Shih, R.W. Haley, Biochem. Biophys. Res. 2018, 505, 87–92
external page https://doi.org/10.1016/j.bbrc.2018.09.083
309
Total Synthesis of Epicolactone
A. G. Kravina, E.M. Carreira, Angew. Chem. Int. Ed. 2018, 57, 13159–13162
external page http://dx.doi.org/10.1002/anie.201807709

308
Unconventional Rose Odorants: Serendipitous Discovery and Unique Olfactory Properties of 2,2-Bis(prenyl)-3-oxobutyronitrile and Its Derivatives
N. Hauser, P. Kraft, E.M. Carreira, Synthesis 2018, 50,4490–4500.
external page http://dx.doi.org/10.1055/s-0037-1610199

307
Trimethyl Orthoacetate and Ethylene Glycol Mono-Vinyl Ether as Enolate Surrogates in Enantioselective Iridium-Catalyzed Allylation
Y. Sempere, E.M. Carreira, Angew. Chem. Int. Ed., 2018, 57, 7654–7658.
external page http://dx.doi.org/10.1002/anie.201803558

306
Synthesis and Structure–Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues
H. Wolleb, S. Ogawa, M. Schneider, A. Shemet, J. Muri, M. Kopf, E.M. Carreira, Org. Lett., 2018, 20, 3014−3016.
external page http://dx.doi.org/10.1021/acs.orglett.8b01042

305
HATRIC-based identification of receptors for orphan ligands
N. Sobotzki, M.A. Schafroth, A. Rudnicka, A. Koetemann, F. Marty, S. Goetze, Y. Yamauchi, E.M Carreira, B. Wollscheid, Nat. Comm. 2018, 9, 1519.
external page http://dx.doi.org/10.1038/s41467-018-03936-z

304
Apoc Social: A Mobile Interactive and Social Learning Platform for Collaborative Solving of Advanced Problems in Organic Chemistry
N. Sievertsen, E.M. Carreira, Chimia, 2018, 72, 43–47.
external page https://doi.org/10.2533/chimia.2018.43
303
Allenylic Carbonates in Enantioselective Iridium-Catalyzed Alkylations
D.A. Petrone, M. Isomura, I. Franzoni, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2018, 140, 4697–4704.
external page http://dx.doi.org/10.1021/jacs.8b01416

302
Natural Products Synthesis: A Personal Retrospective and Outlook
E.M. Carreira, Isr. J. Chem. 2018, 58, 114–121.
external page http://dx.doi.org/10.1002/ijch.201700127
301
Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells
M. Soethoudt, S.C. Stolze, M.V. Westphal, L. van Stralen, A. Martella, E.J. van Rooden, W. Guba, Z.V. Varga, H. Deng, S.I. van Kasteren, U. Grether, A.P. IJzerman, P. Pacher, E.M. Carreira, H.S. Overkleeft, A. Ioan-Facsinay, L.H. Heitman, M. van der Stelt, J. Am. Chem. Soc., 2018, 140, 6067–6075.
external page http://dx.doi.org/10.1021/jacs.7b11281
300
Total Synthesis of (+)-Sarcophytin
L.J. Nannini, Suren J.Nemat, E.M. Carreira, Angew. Chem. Int. Ed., 2018, 130, 831–834.
external page http://dx.doi.org/10.1002/anie.201711372

299
Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling
M.V. Westphal, M.A. Schafroth, R.C. Sarott, M.A. Imhof, C.P. Bold, P. Leippe, A. Dhopeshwarkar, J.M. Grandner, V. Katritch, K. Mackie, D. Trauner, E.M. Carreira, J.A. Frank, J. Am. Chem. Soc. 2017, 139, 18206–18212.
external page http://dx.doi.org/10.1021/jacs.7b06456

298
Total Synthesis of (−)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution
A. Shemet, E.M. Carreira, Org. Lett. 2017, 19, 5529-5532.
external page http://dx.doi.org/10.1021/acs.orglett.7b02619

297
Total Synthesis and Stereochemical Assignment of (+)-Broussonetine H
S.L. Rössler, B.S. Schreib, M. Ginterseder, J.Y. Hamilton, E.M. Carreira, Org. Lett. 2017, 19, 5533–5536.
external page http://dx.doi.org/10.1021/acs.orglett.7b02620

296
Stereochemistry and biological activity of chlorinated lipids: a study of danicalipin A and selected diastereomers
J. Boshkow, S. Fischer, A.M. Bailey, S. Wolfrum, E.M. Carreira, Chem. Sci. 2017, 8, 6904-6910.
external page http://dx.doi.org/10.1039/C7SC03124F

295
Stereoselective Synthesis of Piperidines via Iridium-Catalyzed Cyclocondensation
T. Sandmeier, S.Krautwald, E.M. Carreira, Angew. Chem. Int. Ed. 2017, 56, 11515–11519.
external page http://dx.doi.org/10.1002/anie.201706374

294
Total Synthesis of (+)-Dendrowardol C
H. Wolleb, E.M. Carreira, Angew. Chem. Int. Ed. 2017, 56, 10890–10893.
external page http://dx.doi.org/10.1002/anie.201705809

293
Enantio- and Diastereoselective Spiroketalization Catalyzed by Chiral Iridium Complex
J.Y. Hamilton, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 8082–8085.
external page http://dx.doi.org/10.1021/jacs.7b02856

292
Enantioselective Iridium-Catalyzed Allylic Cyclizations
M.A. Schafroth, S.M. Rummelt, D. Sarlah, E.M. Carreira, Org. Lett. 2017, 19, 3235–3238.
external page http://dx.doi.org/10.1021/acs.orglett.7b01346

291
Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis
M. Hönig, P. Sondermann, N. Turner, E.M. Carreira, Angew. Chem. Int. Ed. 2017, 56, 8942–8973.
external page http://doi.org/10.1002/anie.201612462

290
Cyclopropanation Strategies in Recent Total Syntheses
C. Ebner and E.M. Carreira, Chem. Rev. 2017, 117, 11651–11679.
external page http://dx.doi.org/10.1021/acs.chemrev.6b00798

289
Oxetanyl Amino Acids for Peptidomimetics
G.P. Möller, S. Müller, B.T. Wolfstädter, S. Wolfrum, D. Schepmann, B. Wünsch, E.M. Carreira, Org. Lett. 2017, 19, 2510–2513.
external page http://dx.doi.org/10.1021/acs.orglett.7b00745

288
Stereodivergence in Asymmetric Catalysis
S. Krautwald and E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 5627–5639.
external page http://dx.doi.org/10.1021/jacs.6b13340

287
Study of Intermediates in Iridium–(Phosphoramidite,Olefin)-Catalyzed Enantioselective Allylic Substitution
S.L. Rössler, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 3603–3606.
external page http://dx.doi.org/10.1021/jacs.6b12421

286
Aqueous Instability of δ-Fluorobutylpiperidines
R. Vorberg, E.M. Carreira, K. Müller ChemMedChem 2017, 12, 431–437.
external page http://dx.doi.org/10.1002/cmdc.201700027

285
Partially fluorinated alkoxy groups − Conformational adaptors to changing environments
Q. A. Huchet, N. Trapp, B. Kuhn, B. Wagner, H. Fischer, N.A. Kratochwil, E.M. Carreira, K. Müller, J. Fluorine Chem. 2017, 198, 34–46.
external page http://dx.doi.org/10.1016/j.jfluchem.2017.02.003
284
Bicyclo[3.2.0]heptane as a Core Structure for Conformational Locking of 1,3-Bis-Pharmacophores, Exemplified by GABA
R. Vorberg, E.M. Carreira, K. Müller, Chem. Eur. J. 2017, 23, 3126–3138.
external page http://dx.doi.org/10.1002/chem.201605179
![R. Vorberg, E.M. Carreira, K. Müller, Chem. Eur. J. 2017, 23, 3126–3138. Bicyclo[3.2.0]heptane as a Core Structure for Conformational Locking of 1,3-Bis-Pharmacophores, Exemplified by GABA.](/publications/recent-publications/_jcr_content/par/fullwidthimage_722143290/image.imageformat.1286.1036527510.png)
283
Synthesis of Phytocannabinoids
M.A. Schafroth, E.M. Carreira. In Phytocannabinoids; A. D. Kinghorn, H. Falk, S. Gibbons, J. Kobayashi, Eds.; Progress in the Synthesis of Organic Natural Products Series 103; Springer: Switzerland, 2017; pp 37–59.
external page http://doi.org/10.1007/978-3-319-45541-9_2

282
Enantioselective Addition of Alkynes to α,α-Dichlorinated Aldehydes
Y. Sempere Molina, J. Ruchti, E.M. Carreira, Org. Lett. 2017, 19, 743–745.
external page http://doi.org/10.1021/acs.orglett.6b03692

281
Structural and Conformational Aspects of Equatorial and Axial Trifluoromethyl, Difluoromethyl, and Monofluoromethyl Groups
Q. A. Huchet, W. B. Schweizer, B. Kuhn, E.M. Carreira, K. Müller, Chem. Eur. J. 2016, 22, 16920–16928.
external page http://doi.org/10.1002/chem.201602643

280
Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.
R. Vorberg, N. Trapp, D. Zimmerli, B. Wagner, H. Fischer, N.A. Kratochwil, M. Kansy, E.M. Carreira, K. Müller, ChemMedChem 2016, 11, 2216–2239.
external page http://doi.org/10.1002/cmdc.201600325

279
Rh-Catalyzed Stereospecific Synthesis of Allenes from Propargylic Benzoates and Arylboronic Acids
J. Ruchti, E.M. Carreira, Org. Lett. 2016, 18, 2174–2176.
external page http://doi.org/10.1021/acs.orglett.6b00793

278
Bioisosteric Exchange of Csp3-Chloro and Methyl Substituents: Synthesis and Initial Biological Studies of Atpenin A5 Analogues
S. Krautwald, C. Nilewski, M. Mori, K. Shiomi, S. Ōmura, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 4049–4053.
external page http://doi.org/10.1002/anie.201511672
277
Synthesis and Biological Evaluation of Bromo- and Fluorodanicalipin A.
S. Fischer, N. Huwyler, S. Wolfrum, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 2555–2558.
external page http://dx.doi.org/10.1002/anie.201510608
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276
Formation of α-SF5-Enolate Enables Preparation of 3-SF5-Quinolin-2-ones, 3-SF5-Quinolines, and 3-SF5-Pyridin-2-ones: Evaluation of their Physicochemical Properties.
A. Joliton, J.-M. Plancher, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 2113–2117.
external page http://dx.doi.org/10.1002/anie.201510380

275
A Unified Strategy to Plakortin Pentalenes: Total Syntheses of (±)-Gracilioethers E and F.
S.A. Ruider and E.M. Carreira, Org. Lett. 2016, 18, 220–223.
external page http://dx.doi.org/10.1021/acs.orglett.5b03356

274
Biological Investigations of (+)-Danicalipin A Enabled Through Synthesis.
A.M. Bailey, S. Wolfrum, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 639.
external page http://dx.doi.org/10.1002/anie.201509082
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273
Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery.
Q.A. Huchet, B. Kuhn, B. Wagner, N.A. Kratochwil, H. Fischer, M. Kansy, D. Zimmerli, E.M. Carreira, and K. Müller, Journal of Medicinal Chemistry 2015, 58, 9041.
external page http://dx.doi.org/10.1021/acs.jmedchem.5b01455

272
Synthesis and Biological Evaluation of Chlorinated Analogs of Leukotoxin Diol.
C. Nilewski, C. Le Chapelain, S. Wolfrum, E.M. Carreira, Org. Lett. 2015, 17,5602.
external page http://dx.doi.org/10.1021/acs.orglett.5b02814

271
Stereodivergent Dual Catalytic α-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes.
T. Sandmeier, S. Krautwald, H.F. Zipfel, E.M. Carreira, Angew. Chem. Int. Ed. 2015, 54, 14363.
external page http://dx.doi.org/10.1002/anie.201506933
270
Total Synthesis of Prostaglandin 15d-PGJ2 and Investigation of its Effect on the Secretion of IL-6 and IL-12.
J. Egger, S. Fischer, P. Bretscher, S. Freigang, M. Kopf, E.M. Carreira, Org. Lett. 2015, 17, 4340.
external page http://dx.doi.org/10.1021/acs.orglett.5b02181

269
Pentafulvene for the Synthesis of Complex Natural Products: Total Syntheses of (±)-Pallambins A and B.
C. Ebner, E.M. Carreira, Angew. Chem. Int. Ed. 2015, 54, 11227.
external page http://dx.doi.org/10.1002/anie.201505126

268
A Unified Strategy to 6-5-6-5-6 Membered Epipolythiodiketopiperazines: Studies towards the Total Synthesis of Scabrosin Diacetate and Haematocin.
H.F. Zipfel, E.M. Carreira, Chem. Eur. J. 2015, 21, 12475.
external page http://dx.doi.org/10.1002/chem.201500918
267
Addition of Trifluoroborates Oxetanyl N,O-Acetals: Entry into Spiro and Fused Saturated Heterocycles.
P.B. Brady, E.M. Carreira, Org. Lett. 2015, 17, 3350.
external page http://dx.doi.org/10.1021/acs.orglett.5b01607

266
Iridium-Catalyzed Enantioselective Allylic Alkylation with Functionalized Organozinc-Bromides.
J.Y. Hamilton, D. Sarlah, E.M. Carreira, Angew. Chem. Int. Ed. 2015, 54, 7644.
external page http://dx.doi.org/10.1002/anie.201501851

265
Total Synthesis of Gelsemoxonine through a Spirocyclopropane Isoxazolidine Ring Contraction.
S. Diethelm, E.M. Carreira, J. Am. Chem. Soc. 2015, 137, 6084.
external page http://dx.doi.org/10.1021/jacs.5b02574

264
Formaldehyde N,N-Dialkylhydrazones as Neutral Formyl Anion Equivalents in Iridium-Catalyzed Asymmetric Allylic Substitution.
S. Breitler, E.M. Carreira, J. Am. Chem. Soc. 2015, 137, 5296.
external page http://dx.doi.org/10.1021/jacs.5b01951

263
Stereochemical Studies of the Opening of Chloro Vinyl Epoxides: Cyclic Chloronium Ions as Intermediates.
A. Shemet, D. Sarlah, E.M. Carreira, Org. Lett. 2015, 17, 1878.
external page http://dx.doi.org/10.1021/acs.orglett.5b00558

262
Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.
P. Bretscher, J. Egger, A. Shamshiev, M. Trötzmüller, H. Köfeler, E.M. Carreira, M. Kopf, S. Freigang, EMBO Mol Med 2015, 7, 593.
external page http://dx.doi.org/10.15252/emmm.201404702

261
Novel SF5-Anilines and SF5-Aryl Ethers from SF5-Substituted Potassium Aryl Trifluoroborates.
A. Joliton, E.M. Carreira, Synlett 2015, 26, 737.
external page http://dx.doi.org/10.1055/s-0034-1379981

260
Evaluation of tert-Butyl Isosteres: Case Studies of Physicochemical and Pharmacokinetic Properties, Efficacies, and Activities.
M.V. Westphal, B. T. Wolfstädter, J.-M. Plancher, J. Gatfield, E.M. Carreira, ChemMedChem 2015, 10, 461.
external page http://dx.doi.org/10.1002/cmdc.201402502

259
Iridium-Catalyzed Enantioselective Allylic Vinylation with Potassium Alkenyltrifluoroborates.
J.Y. Hamilton, D. Sarlah, E.M. Carreira, Org. Synth. 2015, 92, 1.
external page http://dx.doi.org/10.15227/orgsyn.092.0001

258
Discovery of a Highly Potent Anti-inflammatory Epoxyisoprostane-Derived Lactone.
J. Egger, P. Bretscher, S. Freigang, M. Kopf, E.M. Carreira, J. Am. Chem. Soc. 2014, 136, 17382.
external page http://dx.doi.org/10.1021/ja509892u

257
Total Synthesis of (±)-Hippolachnin A.
S.A. Ruider, T. Sandmeier, E.M. Carreira, Angew. Chem. Int. Ed. 2014, 53, 2378.
external page http://dx.doi.org/10.1002/anie.201410419

256
Ir-Catalyzed Reverse Prenylation of 3-Substituted Indoles: Total Synthesis of (+)-Aszonalenin and (−)-Brevicompanine B.
J. Ruchti, E.M. Carreira, J. Am. Chem. Soc. 2014, 136, 16756.
external page http://dx.doi.org/10.1021/ja509893s

255
Stereodivergent Total Synthesis of Δ9-Tetrahydrocannabinols.
M.A. Schafroth, G. Zuccarello, S. Krautwald, D. Sarlah, E.M. Carreira, Angew. Chem. Int. Ed. 2014, 53, 13898.
external page http://dx.doi.org/10.1002/anie.201408380
254
Iridium-Catalyzed Enantioselective Allyl–Allylsilane Cross-Coupling.
J.Y. Hamilton, N. Hauser, D. Sarlah, E.M. Carreira, Angew. Chem. Int. Ed. 2014, 53, 10759.
external page http://dx.doi.org/10.1002/anie.201406077
253
Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry.
M. McLaughlin, R. Yazaki, T.C. Fessard, E.M. Carreira, Org. Lett. 2014, 16, 4070.
external page http://dx.doi.org/10.1021/ol501590n

252
Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities.
E.M. Carreira, T.C. Fessard, Chem. Rev. 2014, 114, 8257.
external page http://dx.doi.org/10.1021/cr500127b

251
An Efficient Synthesis Strategy to the Core Structure of 6–5–6–5–6-Membered Epipolythiodiketopiperazines.
H.F. Zipfel, E.M. Carreira, Org. Lett. 2014, 16, 2854.
external page http://dx.doi.org/10.1021/ol500990f

250
Mechanistic Insight into the Spirocyclopropane Isoxazolidine Ring Contraction.
S. Diethelm, F. Schoenebeck, E.M. Carreira, Org. Lett. 2014, 16, 960.
external page http://dx.doi.org/10.1021/ol403693t

249
Efficient Synthesis Strategies by Application of Transition Metal-Catalyzed Carbene/Nitrene Insertions into C–H Bonds.
J. Egger, E.M. Carreira, Nat. Prod. Rep. 2014, 31, 449.
external page http://dx.doi.org/10.1039/C3NP70084D

248
Stereodivergent α-Allylation of Linear Aldehydes with Dual Iridium and Amine Catalysis.
S. Krautwald, M.A. Schafroth, D. Sarlah, E.M. Carreira, J. Am. Chem. Soc. 2014, 136, 3020.
external page http://dx.doi.org/10.1021/ja5003247

247
Iridium-Catalyzed Enantioselective Allyl–Alkene Coupling.
J.Y. Hamilton, D. Sarlah, E.M. Carreira, J. Am. Chem. Soc. 2014, 136, 3006.
external page http://dx.doi.org/10.1021/ja412962w

246
Autotandem Catalysis with Ruthenium: Remote Hydroesterification of Allylic Amides.
N. Armanino, M. Lafrance, E.M. Carreira, Org. Lett. 2014, 16, 572.
external page http://dx.doi.org/10.1021/ol4034463
