Chemical Biology
Synthesis of Cannabinoids and their Application in the Elucidation of Receptor Expression and Signaling Pathways:
For more information, check out the following publications:
- external page R. C. Sarott, A. E. G. Viray, P. Pfaff, A. Sadybekov, G. Rajic, V. Katritch, E. M. Carreira, J. A. Frank, J. Am. Chem. Soc., 2021, 143, 736–743.
- external page R. C. Sarott, M. Westphal, P. Pfaff et. al, J. Am. Chem. Soc., 2020, 142, 16953–16964.
- external page M.V. Westphal, R.C. Sarott, E.A. Zirwes, A. Osterwald, W. Guba, C. Ullmer, U. Grether, E.M. Carreira, Chem. Eur. J. 2020, 26, 1380–1387.
- external page M. Soethoudt, S.C. Stolze, M.V. Westphal, L. van Stralen, A. Martella, E.J. van Rooden, W. Guba, Z.V. Varga, H. Deng, S.I. van Kasteren, U. Grether, A.P. IJzerman, P. Pacher, E.M. Carreira, H.S. Overkleeft, A. Ioan-Facsinay, L.H. Heitman, M. van der Stelt, J. Am. Chem. Soc., 2018, 140, 6067–6075.
- external page M.V. Westphal, M.A. Schafroth, R.C. Sarott, M.A. Imhof, C.P. Bold, P. Leippe, A. Dhopeshwarkar, J.M. Grandner, V. Katritch, K. Mackie, D. Trauner, E.M. Carreira, J.A. Frank, J. Am. Chem. Soc. 2017, 139, 18206–18212.
Design and Synthesis of photoswitchable PROTACs (photoPROTACs) for Reversible Optical Control of Induced Protein Degradation.
For more information, check out the following publication:
Chemoproteomic tools for the identification of ligand-receptor interactions on living cells:
For more information, check out the following publications:
- external page A.P. Frei, O-Y. Jeon, S. Kilcher, H. Moest, L.M. Henning, C. Jost, A. Plückthun, J. Mercer, R. Aebersold, E.M. Carreira, B. Wollscheid, Nat. Biotech. 2012, 30, 997–1001.
- external page N. Sobotzki, M.A. Schafroth, A. Rudnicka, A. Koetemann, F. Marty, S. Goetze, Y. Yamauchi, E.M. Carreira, B. Wollscheid, Nat. Comm. 2018, 9, 1519.
Total Synthesis and SAR Studies of Prostaglandin 15d-PGJ2 and Related Isoprostanes:
For more information, check out the following publications:
- external page H. Wolleb, S. Ogawa, M. Schneider, A. Shemet, J. Muri, M. Kopf, E.M. Carreira, Org. Lett., 2018, 20, 3014−3016.
- external page J. Egger, S. Fischer, P. Bretscher, S. Freigang, M. Kopf, E. M. Carreira, Org. Lett. 2015, 17, 4340.
- external page P. Bretscher, J. Egger, A. Shamshiev, M. Trötzmüller, H. Köfeler, E. M. Carreira, M. Kopf, S. Freigang, EMBO Mol Med 2015, 7, 593.
- external page J. Egger, P. Bretscher, S. Freigang, M. Kopf, E. M. Carreira, J. Am. Chem. Soc. 2014, 136, 17382.
- external page J. Egger, P. Bretscher, S. Freigang, M. Kopf, E. M. Carreira, Angew. Chem. Int. Ed. 2013, 52, 5382.
Synthesis, Biological Evaluation and Use as a Bioprobe of Amphotericin B and its Derivatives:
For more information, check out the following publications:
- external page A.R. Everitt, S. Clare, J.M. Perreira, G. Savidis, A.M. Aker, S.P. John, D. Sarlah, E.M. Carreira, S.J. Elledge, P. Kellam, A.L. Brass, Cell Reports 2013, 5, 895.
- external page M.P. Croatt, E.M. Carreira, Org. Lett. 2011, 13, 1390.
- external page A.A. Volmer, A.M. Szpilman, E.M. Carreira, Nat. Prod. Rep. 2010, 27, 1329.
- external page A.A. Volmer, E.M. Carreira, ChemBioChem 2010, 11, 778.
- external page A.M. Szpilman, D.M. Cereghetti, J.M. Manthorpe, N.R. Wurtz, E.M. Carreira, Chem. Eur. J. 2009, 15, 7117.
- external page A. Zumbuehl, P. Stano, M. Sohrmann, R. Dietiker, M. Peter, E.M. Carreira, ChemBioChem 2009, 10, 1617.
- external page A.M. Szpilman, J.M. Manthorpe, E.M. Carreira, Angew. Chem. Int. Ed. 2008, 47, 4339.
- external page A.M. Szpilman, D.M. Cereghetti, N.R. Wurtz, J.M. Manthorpe, E.M. Carreira, Angew. Chem. Int. Ed. 2008, 47, 4335.
- external page V. Paquet, A.A. Volmer, E.M. Carreira, Chem. Eur. J. 2008, 14, 2465.
- external page A. Zumbuehl, P. Stano, M. Sohrmann, M. Peter, P. Walde, E.M. Carreira, Org. Biomol. Chem. 2007, 5, 1339.
- external page V. Paquet, A. Zumbuehl, E.M. Carreira, Bioconjugate Chem. 2006, 17, 1460.
- external page D.M. Cereghetti, E.M. Carreira, Synthesis 2006, 914.